Transgenic flies expressing tau and amyloid precursor fragment

Details Transgenic flies expressing tau and amyloid precursor fragment Transgenic flies expressing tau and amyloid precursor fragment

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/00 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2655634

The present invention discloses a transgenic fly that expresses a carboxy terminal fragment of the human amyloid-.beta. precursor protein (APP) and a double transgenic fly that expresses both the fragment of APP and tau protein. The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.

L'invention porte sur une mouche transgénique exprimant un fragment carboxyle terminal de la protéine précurseur de l'amyloïde-.beta. (APP) et sur une mouche doublement transgénique exprimant à la fois le fragment de l'APP et la protéine tau. Lesdites mouches fournissent des modèles de troubles neurodégénératifs tels que la maladie d'Alzheimer. L'invention porte également des méthodes d'identification de modificateurs génétiques et sur des méthodes d'identification de composés thérapeutiques pouvant traiter des troubles neurodégénératifs recourant aux mouches transgéniques.

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