Nicotinamide derivatives useful as pde4 inhibitors

Details Nicotinamide derivatives useful as pde4 inhibitors Nicotinamide derivatives useful as pde4 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/443 (2006.01) A61K 31/4433 (2006.01) A61K 31/455 (2006.01) A61K 31/46 (2006.01) A61K 45/06 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) C07D 213/82 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 451/10 (2006.01)

Patent

CA 2475708

The invention relates to nicotinamide derivatives of formula (1) and to processes for the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are phosphodiesterase-4 inhibitors and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions as well as for wounds healing.

L'invention concerne des dérivés de nicotinamide de formule (1) et des procédés de préparation de ces dérivés, des compositions les contenant et les utilisations de tels dérivés. Ces dérivés sont des inhibiteurs de phosphodiesterase-4 et sont utiles dans de nombreuses maladies, troubles et états de santé, en particulier des maladies, des troubles et états de santé inflammatoires, allergiques et respiratoires ainsi que pour la cicatrisation de blessures.

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