Method of treatment using ligand-immunogen conjugates

Details Method of treatment using ligand-immunogen conjugates Method of treatment using ligand-immunogen conjugates

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/00 (2006.01) A61K 31/7084 (2006.01) A61K 38/00 (2006.01) A61K 38/21 (2006.01) A61K 39/00 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) A61K 45/00 (2006.01) A61K 47/22 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2461877

A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic cells preferentially express, uniquely express or overexpress abinding site for a particular ligand. The invention comprises administering to a host animal harboring the population of pathogenic cells the ligand conjugated to an immunogen capable of activating a toll-like receptor. At least one additional therapeutic factor can be administred wherein the therapeutic factor is a compound capable of stimulating an endogenous immune response wherein the compound does not bind to the ligand-immunogen conjugate.

L'invention concerne une méthode et une composition pharmaceutique destinées à améliorer l'élimination induite par réponse immunitaire endogène d'une population de cellules pathogènes chez un animal hôte, ces cellules pathogènes exprimant préférentiellement ou uniquement ou surexprimant un site de liaison pour un ligand particulier. La méthode de l'invention consiste à administrer à un animal hôte hébergeant cette population de cellules pathogènes le ligand conjugué à un immunogène capable d'activer un récepteur de type Toll. Au moins un facteur thérapeutique peut également être administré. Ce facteur thérapeutique est un composé capable de stimuler une réponse immunitaire endogène, ledit composé ne se liant pas au conjugué ligand-immunogène.

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