Instant granules and process for their formulation

Details Instant granules and process for their formulation Instant granules and process for their formulation

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/00 (2006.01) A61K 31/198 (2006.01) A61K 31/405 (2006.01)

Patent

CA 2396223

The pharmaceutical formulation according to the invention is in the form of instant granules, in which the surface of the particles of at least two different soluble carrier materials is covered or coated with at least one layer which contains of from 50 to 120, preferably from about 60 to about 100, parts by weight of active substance per 100 parts by weight of carrier material of at least one, preferably insoluble or slightly soluble, active substance, such as amino acids or antioxidants. A first carrier material constitutes from about 50 to about 80 % by weight of the total carrier material and is selected from carrier materials having a bulk density of between 58 and 100, preferably between 63 and 90 g/100 ml, while the second carrier material is selected from carrier materials having a bulk density of between 30 to 55, preferably between 33 and 50 g/100 ml.

Cette invention se rapporte à une formulation pharmaceutique se présentant sous la forme de granules instantanés, dans lesquels la surface des particules d'au moins deux matériaux véhicules solubles différents est recouverte ou enduite d'au moins une couche qui contient au moins une substance active, de préférence insoluble ou légèrement soluble, telle que des acides aminés ou des anti-oxydants, selon une quantité comprise entre 50 et 120, de préférence entre environ 60 et environ 100, parties en poids de substance active pour 100 parties en poids de matériau véhicule. Un premier matériau véhicule constitue environ 50 à environ 80 % en poids du matériau véhicule total et ce premier matériau véhicule est choisi parmi des matériaux véhicules ayant une densité apparente comprise entre 58 et 100, de préférence entre 63 et 90 g/100 ml, alors que le second matériau véhicule est choisi parmi des matériaux véhicules ayant une densité apparente comprise entre 30 et 55, de préférence entre 33 et 50 g/100 ml.

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