Protease-resistant thrombomodulin analogs

Details Protease-resistant thrombomodulin analogs Protease-resistant thrombomodulin analogs

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/745 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2129370

2129370 9315755 PCTABS00024 The present invention relates to the single-chain thrombomodulin ("TM") and analogs thereof that are not susceptible to cleavage by proteases and retain the biological activity of thrombomodulin, as well as methods of use in, for example, antithrombotic therapy. Novel proteins, nucleic acid gene sequences, pharmaceuticals and methods of inhibiting thrombotic activity are disclosed.

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