C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/51 (2006.01) A61K 39/29 (2006.01) A61K 39/42 (2006.01) C07K 14/085 (2006.01) C07K 16/10 (2006.01) G01N 33/576 (2006.01)
Patent
CA 2201588
A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
L'invention se rapporte à une souche du virus de l'hépatite E provenant du Pakistan (SAR-55) impliquée dans une épidémie d'hépatite non A, non B transmise de manière entérique, et appelée aujourd'hui hépatite E. L'invention se rapporte en outre à l'expression de toute la région structurale de SAR-55, nommée cadre de lecture ouvert 2 (ORF-2), dans un système d'expression eucaryotique. La protéine exprimée est capable de former des particules analogues au virus VHE (virus de l'hépatite E) qui peuvent être utilisées comme antigènes dans des essais immunologiques de diagnostic, et comme immunogènes ou vaccins destinés à protéger contre des infections dues à l'hépatite E.
Emerson Suzanne U.
Purcell Robert H.
Tsarev Sergei A.
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Smart & Biggar
LandOfFree
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