A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 9/00 (2006.01) A61K 31/34 (2006.01) A61K 31/44 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2415695
There is provided a pharmaceutical composition comprising isosorbide dinitrate, wherein said composition is in the form of an aqueous gel containing not more than about 15 wt. % of a water-soluble lipophilic substance. Optionally, the gel may comprise a calcium channel blocker as an additional active ingredient, A composition comprising diisosorbide dinitrate and nifedipine is also disclosed. There is also provided a method for treating anal fissure, comprising applying to a locus in need of such treatment an efficacious amount of a composition according to the invention.
L'invention concerne une composition pharmaceutique composée de dinitrate d'isosorbide, dans laquelle la dite composition se présente sous forme de gel aqueux ne contenant pas plus de 15 % par poids de substance lipophile soluble dans l'eau. Le gel peut éventuellement contenir un bloqueur de canal calcium comme ingrédient actif supplémentaire. L'invention concerne également une composition contenant du dinitrate de diisosorbide et du nifédipine. Enfin, l'invention concerne un procédé de traitement d'une fissure anale consistant à appliquer sur une zone nécessitant un tel traitement une quantité efficace de ladite composition préparée conformément à la présente invention.
Fiscure Ltd.
Jossifoff Azariah
Smart & Biggar
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