C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) C12M 1/34 (2006.01) C12M 1/42 (2006.01) C12N 1/00 (2006.01) C12N 13/00 (2006.01) G01N 1/00 (2006.01)
Patent
CA 2493101
A device for monitoring the migration or invasion of a biological particle such as a cell is disclosed. The device includes an upper chamber adapted to receive and retain a cell sample, a lower chamber having at least two electrodes, and a biocompatible porous membrane having a porosity sufficient to allow cells to migrate therethrough. The membrane is disposed in the device so as to separate the upper and lower chambers from one another. Migration of cells through the porous membrane permits contact between the migrating cells and one or more electrodes of the lower chamber. The contact provides a detectable change in impedance between or among the electrodes.
La présente invention concerne un dispositif permettant de surveiller la migration ou l'invasion d'une particule biologique telle qu'une cellule. Ce dispositif comprend une chambre supérieure conçue pour recevoir et retenir un échantillon de cellule, une chambre inférieure possédant au moins deux électrodes et une membrane poreuse biocompatible dont la porosité est suffisante pour laisser des cellules migrer à travers cette membrane. Cette membrane est placée dans le dispositif de façon à séparer l'une de l'autre la chambre supérieure et la chambre inférieure. La migration de cellules à travers la membrane poreuse permet un contact entre ces cellules migrantes et une ou plusieurs électrodes de la chambre inférieure. Ce contact permet d'obtenir un changement d'impédance détectable entre les électrodes ou parmi celles-ci.
Wang Xiaobo
Xu Xiao
Acea Biosciences Inc.
Ridout & Maybee Llp
LandOfFree
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