Transferrin variants and conjugates

Details Transferrin variants and conjugates Transferrin variants and conjugates

C - Chemistry, Metallurgy

07

K

C07K 14/79 (2006.01) A61K 38/40 (2006.01) A61K 47/48 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2695830

Based on the three-dimensional structure of transferrin, the inventors have designed variant polypeptides (muteins) which have one or more Cysteine residues with a free thiol group (hereinafter referred to as thiotransferrin ). The variant polypeptide may be conjugated through the sulphur atom of the Cysteine residue to a bioactive compound.

L'invention concerne des polypeptides variants (mutéines) qui comprennent un ou plusieurs résidus cystéine avec un groupe thiol libre (désignés ci-dessous par thiotransferrine), conçus par les inventeurs d'après la structure tridimensionnelle de la transferrine. Le polypeptide variant peut être conjugué à un composé bioactif par l'intermédiaire d'un atome de soufre du résidu cystéine.

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