Biopolymer conjugates comprising an interleukin-11 analog

Details Biopolymer conjugates comprising an interleukin-11 analog Biopolymer conjugates comprising an interleukin-11 analog

A - Human Necessities

61

K

A61K 38/20 (2006.01)

Patent

CA 2730721

The present invention provides for biopolymer conjugates of an IL-11 analog (mIL-11) and a biocompatible polymer. The mIL-11 of the invention displays an enhanced resistance to acidolysis and shows increased stability as compared to rhIL-11. The conjugates of the present invention are characterized by a longer serum half-life and exhibit essentially no loss of activity as compared to the corresponding unconjugated mIL-11. Image

La présente invention concerne des conjugués de biopolymère d'un analogue d'IL-11 (mIL-11) et d'un polymère biocompatible. Le mIL-11 de l'invention présente une résistance accrue à l'acidolyse et présente une stabilité accrue par comparaison avec rhIL-11. Les conjugués de la présente invention sont caractérisés par une demi-vie sérique plus longue et ne présentent pour l'essentiel pas de perte d'activité par comparaison avec le mIL-11 non conjugué correspondant.

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