C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/22 (2006.01) A61K 31/337 (2006.01) A61K 31/4745 (2006.01) A61K 31/7068 (2006.01) A61P 35/00 (2006.01) C07D 305/14 (2006.01) C07H 19/067 (2006.01) C12Q 1/26 (2006.01) C12Q 1/34 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2468170
The present invention relates to a method for identification of enzymes that are preferentially expressed in certain tumor tissue as compared with rapidly growing normal cells or tissue, use of said enzymes for the compound design to generate an active anticancer substance selectively in tumor tissue, compounds designed based on said enzymes, their pharmaceutically acceptable salts as well as pharmaceutical composition thereof.
La présente invention concerne un procédé d'identification d'enzymes exprimées majoritairement dans certains tissus tumoraux par rapport à des cellules ou tissus à croissance rapide ou normale. L'invention concerne également l'utilisation desdites enzymes pour l'élaboration de composés servant à produire sélectivement une substance anticancéreuse active dans des tissus tumoraux, les composés élaborés sur la base desdites enzymes, leurs sels pharmaceutiquement acceptables ainsi qu'une composition pharmaceutique desdits composés et sels.
Ishitsuka Hideo
Okabe Hisafumi
Shimma Nobuo
Tsukuda Takuo
Umeda Isao
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Chugai Seiyaku Kabushiki Kaisha
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