Method of manufacture of 1,3-oxathiolane nucleosides

Details Method of manufacture of 1,3-oxathiolane nucleosides Method of manufacture of 1,3-oxathiolane nucleosides

C - Chemistry, Metallurgy

07

H

C07H 19/173 (2006.01) C07D 327/04 (2006.01) C07D 411/04 (2006.01) C07H 19/073 (2006.01)

Patent

CA 2714085

Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.

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