Prolonged release drug tablet formulations

Details Prolonged release drug tablet formulations Prolonged release drug tablet formulations

A - Human Necessities

61

K

167/158, 167/172

A61K 31/455 (2006.01) A61K 9/54 (2006.01) A61K 9/62 (2006.01)

Patent

CA 2030449

ABSTRACT OF THE INVENTION A prolonged-release unit dosage formulation or pharmaceutical composition, preferably in tablet form, is described. The composition consists essentially of a gel-forming dietary fiber, a biologically-absorbable drug or other active therapeutic agent, and certain specific disintegrants, namely, a physiologically- acceptable edible acid and a mineral salt which releases a physiologically-acceptable gas upon inges- tion, preferably carbon dioxide, e.g., a mineral carbonate or bicarbonate, and advantageously dextrose or like soluble sugar. The dietary fiber-containing composition, when compressed into a tablet together with the drug and the specific disintegrants, provides a unique and efficient prolonged-action drug-delivery system. HK 5/dlk

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