Stable formulations of mhc-peptide complexes

Details Stable formulations of mhc-peptide complexes Stable formulations of mhc-peptide complexes

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 38/17 (2006.01) A61K 39/385 (2006.01) A61K 47/26 (2006.01) C07K 14/47 (2006.01) C07K 14/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223605

The present invention provides stable pharmaceutical compositions comprising MHC-peptide complexes and an alkylglycoside detergent. The compositions are useful for inhibiting T-cell mediated immune response associated with various diseases, such as autoimmunity, and allergies.

La présente invention concerne des compositions pharmaceutiques stables comprenant des complexes de peptides du CMH (complexe majeur d'histocompatibilité), ainsi qu'un détergent à base d'alkylglycoside. Ces compositions sont utiles pour inhiber la réponse immune induite par les lymphocytes T et associée à plusieurs maladies, telles que l'auto-immunité et des allergies.

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