C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) B82B 3/00 (2006.01) C12N 7/00 (2006.01) H01L 29/772 (2006.01) H01L 51/00 (2006.01) H01L 51/05 (2006.01)
Patent
CA 2542674
One-dimensional ring structures from M13 viruses were constructed by two genetic modifications encoding binding peptides and synthesis of a heterobifunctional linker molecule. The bifunctional viruses displayed an anti- streptavidin peptide and hexahistidine peptide at opposite ends of the virus as pIII and pIX fusions. Stoichiometric addition of the streptavidin-NiNTA linker molecule led to the reversible formation of virus-based nanorings with circumferences corresponding to lengths of the packagable DNAs. These virus- based ring structures can be further engineered to nucleate inorganic materials and form metallic, magnetic, or semiconductor nanorings using trifunctionalized viruses.
Des structures cycliques unidimensionnelles ont été construites à partir de virus M13 par deux modification génétiques consistant à coder des peptides de liaison et à synthétiser une molécule de liaison hétérobifonctionnelle. Les virus bifonctionnels présentaient un peptide anti-streptavidine et un peptide hexahistidine aux extrémités opposées du virus comme fusions pIII et pIX. L'ajout stoechiométrique de la molécule de liaison streptavidine-NiNTA a conduit à la formation réversible des nanocycles viraux avec des circonférences correspondant aux longueurs des ADN conditionnables. Ces structures cycliques virales peuvent être davantage modifiées pour nucléer des matériaux inorganiques et former des nanocycles métalliques, magnétiques ou semi-conducteurs à partir de virus trifonctionnalisés.
Belcher Angela M.
Nam Ki Tae
Peele Beau
Board Of Regents The University Of Texas System
Massachusetts Institute Of Technology
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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