Compositions and methods of modulating an immune response to...

A - Human Necessities – 61 – K

Patent

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A61K 39/00 (2006.01) A01N 63/00 (2006.01) A61K 38/19 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2328604

The invention provides for methods of vaccinating a mammal to a selected antigen, the methods comprising administering to a mammal a vaccine composition comprising a CD40 ligand-enchanced cell, or a cytokine-coated cell, wherein the CD40 ligand-enchanced cell comprises a selected antigen and is admixed with an engineered ligand for CD40, or wherein a cytokine-coated cell comprises a selected antigen and is admixed with an engineered cytokine.

Cette invention porte sur des procédés permettant de vacciner un mammifère contre un antigène sélectionné. Ces procédés consistent en l'administration au mammifère considéré d'une composition vaccinale comprenant une cellule renforcée par un ligand CD40 ou une cellule enrobée de cytokine. En l'occurrence, cette cellule qui est renforcée par un ligand CD40 et qui comprend un antigène sélectionné est ajoutée et mélangée à un ligand caractéristique du CD40 obtenu par génie génétique. Sinon, la cellule enrobée de cytokine et qui comprend un antigène sélectionné, est ajoutée et mélangée à une cytokine obtenue par génie génétique.

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