Human antipneumococcal antibodies from non-human animals

Details Human antipneumococcal antibodies from non-human animals Human antipneumococcal antibodies from non-human animals

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 31/18 (2006.01) C07K 16/12 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2447114

The invention described herein provides human antibodies produced in non-human animals that specifically bind to Streptococcus pneumoniae capsular polysaccharide (PPS-3). The invention further provides methods for making the antibodies in a non-human animal and for expressing the antibodies in cells including hybridomas and recombinant host cell systems. Kits and pharmaceutical compositions comprising the antibodies are also provided in addition to methods of treating, inhibiting or preventing S. pneumoniae infection or conditions or disorders caused by such infection by administering to a patient the pharmaceutical compositions described herein.

La présente invention concerne des anticorps humains produits dans des animaux non humains qui se lient spécifiquement au polysaccharide capsulaire (PPS-3) de Streptococcus pneumoniae. L'invention se rapporte également à des procédés permettant de fabriquer les anticorps précités dans un animal non humain et d'exprimer lesdits anticorps dans des cellules comprenant des hybridomes et des systèmes de cellules hôtes recombinées. L'invention concerne en outre des trousses et des compositions pharmaceutiques comprenant les anticorps de l'invention, ainsi que des procédés permettant de traiter, d'inhiber ou de prévenir l'infection par S. pneumoniae ou les états ou troubles provoqués par cette infection en administrant au patient les compositions pharmaceutiques précitées.

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