A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/21 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 39/42 (2006.01) A61P 31/18 (2006.01) C07K 14/16 (2006.01) C07K 14/73 (2006.01) C07K 16/10 (2006.01) C07K 16/28 (2006.01) C12N 5/16 (2006.01) C12N 15/62 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2497662
(A) Pharmaceutical composition for treating/preventing HIV comprising (i) a polynucleotide encoding HIV envelope protein and (ii) a polynucleotide encoding CD4 receptor protein or; (i) a polynucleotide encoding HIV envelope protein and (ii) a CD4 receptor protein or; a fixed cell expressing an HIV envelope protein complexed with a CD4 receptor protein also disclosed are (B) pharmaceutical compositions for treating/preventing HIV comprising an antibody immunospecific for a fixed cell expressing an HIV envelope protein complexe with a CD4 receptor protein. The binding of the CD4 to the HIV envelope protein, i.e. gp120, exposes hidden epitopes that may be used as targets in immunotherapie; the presentation of the gp120 and CD4 in the present forms is said to overcome problems with prior art soluble gp120-CD4 complexes.
Cette invention concerne une composition pharmaceutique comprenant (i) un polynucléotide codant pour une protéine d'enveloppe du VIH et (ii) un polynucléotide codant pour un récepteur CD4.
Burastero Samuele E.
Lusso Paolo
Fondazione Centro San Raffaele Del Monte Tabor
Smart & Biggar
LandOfFree
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