Topical drug delivery system

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/08 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2730787

A drug delivery system for topical administration of a therapeutic agent. The drug delivery system comprising: (a) a therapeutic agent, (b) a vicinal alkane diol, (c) a C8-C34 fatty acid or corresponding alcohol or ester having a melting point below 40°C, (d) a volatile solvent, such as a short chain alcohol or volatile silicone. The therapeutic agent being present in an amount such that upon topical application to a surface, evaporation of the volatile component occurs such that the remaining solution is at least 90% saturated with the therapeutic agent at the temperature of the surface.

L'invention concerne un système d'apport de médicament pour l'administration topique d'un agent thérapeutique. Ce système d'apport de médicament comprend: (a) un agent thérapeutique, (b) un diol alcane voisin, (c) un acide gras en C8-C34 ou un alcool ou ester correspondant dont le point de fusion est inférieur à 40°C, (d), un solvant volatil, tel qu'un alcool à chaîne courte ou qu'un silicone volatil. L'agent thérapeutique étant présent dans une quantité telle que lors de l'application topique sur une surface, l'évaporation du composant volatil survient de façon que la solution restante est au moins saturée à 90 % avec l'agent thérapeutique à la température de la surface.

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