C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01) A61K 31/4439 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 413/04 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2443234
The present invention provides compounds of formula I: wherein A is N or CR, and R1, G and R2, are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of Src mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
La présente invention concerne des composés représentés par la formule I. Dans cette formule A est N ou CR et R¿1?, G et R¿2? sont tels que décrits dans les spécifications. Ces composés sont des inhibiteurs de protéine kinase, en particulier de protéine kinase Src de mammifère impliquée dans la prolifération cellulaire, dans la mort cellulaire et dans la réponse aux stimuli extracellulaires. Cette invention concerne aussi des techniques de production de ces inhibiteurs. Cette invention concerne enfin des compositions pharmaceutiques comprenant ces inhibiteurs et des techniques d'utilisation de ces compositions dans le traitement et la prévention de pathologies diverses.
Smart & Biggar
Vertex Pharmaceuticals Incorporated
LandOfFree
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