Collagen-polysaccharide matrix for bone and cartilage repair

Details Collagen-polysaccharide matrix for bone and cartilage repair Collagen-polysaccharide matrix for bone and cartilage repair

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61K 47/36 (2006.01) A61K 47/42 (2006.01) A61L 27/00 (2006.01) A61L 27/24 (2006.01) A61L 27/26 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2277110

A matrix and a method for preparing it are provided to support the growth of tissue, such as bone, cartilage or soft tissue. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent linkages to collagen.

Cette invention se rapporte à une matrice, ainsi qu'à un procédé de préparation associé, ladite matrice servant à favoriser la croissance de tissu du type os, cartilage ou tissu mou. On fait réagir un polysaccharide avec un agent d'oxydation afin d'ouvrir les cycles glucidiques sur le polysaccharide de façon à former des groupes aldéhyde. On fait ensuite réagir ces groupes aldéhyde de manière à former des liaisons covalentes avec le collagène.

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