Compositions and methods for use in ischemia-reperfusion and...

A - Human Necessities – 61 – K

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A61K 31/52 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) A61K 31/515 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2312867

Methods of preventing or treating ischemia-reperfusion injury in an organ by administration of a composition containing a selective A1 adenosine receptor antagonist and/or a P2X purinoceptor antagonist are provided. Methods of preventing or treating endotoxin-related tissue injury by administration of a composition containing a selective A1 adenosine receptor antagonist and/or a P2X purinoceptor antagonist are also provided.

L'invention concerne des traitements préventifs ou curatifs des lésions liées à la reperfusion d'une ischémie dans un organe, comprenant l'administration d'une composition contenant un antagoniste sélectif du récepteur d'adénosine A¿1? et/ou un antagoniste du purinorécepteur P¿2X?. L'invention concerne également des traitements préventifs et curatifs des lésions tissulaires d'origine endotoxinique comprenant l'administration d'une composition contenant un antagoniste sélectif du récepteur d'adénosine A¿1? et/ou un antagoniste du purinorécepteur P¿2X?.

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