Sulfonamides as cell adhesion inhibitors

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 5/06 (2006.01) A61K 31/198 (2006.01) A61K 31/381 (2006.01) A61K 31/4406 (2006.01) A61K 38/05 (2006.01) A61P 29/00 (2006.01) C07C 311/18 (2006.01) C07C 311/29 (2006.01) C07D 213/55 (2006.01) C07D 333/24 (2006.01)

Patent

CA 2291708

Compounds of formula (I) are antagonists of VLA-4 and/or .alpha.4-.beta.7, and as such are useful in the inhibition or prevention of cell adhesion and cell- adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.

Les composés correspondant à la formule (I) sont des antagonistes de VLA-4 et/ou de .alpha.¿4?.beta.¿7? et sont, en tant que tels, utiles pour inhiber ou empêcher l'adhérence cellulaire et des pathologies induites par l'adhérence cellulaire. Ces composés peuvent être formulés sous forme de compositions pharmaceutiques et peuvent être utilisés dans le traitement de l'asthme, des allergies, des inflammations, de la sclérose en plaques et d'autres maladies inflammatoires et auto-immunes.

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