At1-receptor antagonists for preventing and treating...

Details At1-receptor antagonists for preventing and treating... At1-receptor antagonists for preventing and treating...

A - Human Necessities

61

K

A61K 31/41 (2006.01) A61K 31/00 (2006.01) A61K 31/415 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 31/455 (2006.01) A61K 31/4709 (2006.01)

Patent

CA 2232663

AT1-receptor antagonists and particularly the compound (S)-N-(1-carboxy-2-methylprop-1-yl)-N--pentanoyl-N-[2' (1H-tetrazol-5- yl)biphenyl--4-yl-methyl]amine (valsartan) of formula (I) or a salt thereof, in particular a pharmaceutically acceptable salt thereof, can be used for treating (acute and chronic) postischemic renal failure and for protecting the ischemic kidney.

On décrit des antagonistes du récepteur d'AT1 et notamment le composé (S)-N-(1-carboxy-2-méthylprop-1-yl)-N-pentanoyl-N-[2'(1H-tétrazol-5-yl)biphényl-4-yl-méthyl]amine (valsartan) de la formule (I), ou un sel de celui-ci, particulièrement un sel de celui-ci acceptable sur le plan pharmacologique. On peut utiliser ces composés pour traiter l'insuffisance rénale postischémique (aiguë ou chronique) et pour protéger le rein ischémié.

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