Inhibitors of stim1 for the treatment of cardiovascular...

Details Inhibitors of stim1 for the treatment of cardiovascular... Inhibitors of stim1 for the treatment of cardiovascular...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61M 25/00 (2006.01) A61P 9/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2720887

The invention relates to inhibitors of STIM1 for the treatment and/or the prevention of cardiac disorders such as atherosclerosis, post-angioplasty restenosis, pulmonary arterial hypertension, vein-graft disease, cardiac hypertrophy, cardiac ar-rhythmias, valvulopathies, diastolic dysfunction, chronic heart failure, ischemic heart failure, and myocarditis.

Linvention concerne des inhibiteurs de STIM1 pour le traitement et/ou la prévention de troubles cardiaques tels que lathérosclérose, une resténose postangioplastie, une hypertension artérielle pulmonaire, une maladie de greffe veineuse, une hypertrophie cardiaque, des arythmies cardiaques, des valvulopathies, un dysfonctionnement diastolique, une insuffisance cardiaque chronique, une insuffisance cardiaque ischémique et une myocardite.

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