Serum amyloid a protein

Details Serum amyloid a protein Serum amyloid a protein

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2220708

A method is provided for potentiating the release and collection of cholesterol from inflammatory or atherosclerotic sites in vivo, the method including the steps of increasing the affinity of high-density lipoprotein for macrophages by administering to a patient an effective amount of a composition comprising a compound selected from the group consisting of native serum amyloid A (SAA) and a ligand having SAA properties thereby increasing the affinity of high density lipoprotein (HDL) for macrophages and potentiating release and collection of cholesterol.

L'invention porte sur un procédé permettant de potentialiser la libération et le recueil du cholestérol à partir de sites inflammatoires ou athéroscléreux in vivo. Le procédé consiste à augmenter l'affinité des lipoprotéines de haute densité pour les macrophages par administration à un patient d'une dose efficace d'une composition comprenant un composé choisi dans le groupe constitué d'amyloïde sérique A natif (SAA) et d'un ligand aux propriétés SAA. Il en résulte une augmentation de l'affinité des lipoprotéines de haute densité (HDL) pour les macrophages et une potentialisation de la libération et du recueil du cholestérol.

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