C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/075 (2006.01)
Patent
CA 2066464
.alpha.-L-Aspartyl-L-phenylalanine methyl ester (.alpha.-APM) is prepared by catalytic hydrogenation of N-benzyloxy- carbonyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester (Z- .alpha.-APM). The catalytic hydrogenation is conducted in an aqueous suspension containing the Z-.alpha.-APM in the form of particles whose average particle size is not greater than 800 µm. The starting Z-.alpha.-APM may contain up to 30 wt.% of its .beta.-isomer provided that the process additionally includes recrystallization of the .alpha.-APM, collection of the .alpha.-APM by filtration and recycling of the filtrate for use in the aqueous suspension of Z-.alpha.-APM.
Ester méthylique d'alpha-L-Aspartyl-L-phénylalanine (alpha-APM), préparé par hydrogénation catalytique de l'ester méthylique de N-benzyloxy-carbonyl-alpha-L-aspartyl-L-phénylalanine (Z-alpha-APM). L'hydrogénation catalytique est faite dans une suspension aqueuse renfermant le Z-alpha-APM sous forme de particules dont la taille moyenne ne dépasse pas 800 microns. Le Z-alpha-APM de départ peut contenir jusqu'à 30 % en poids de son isomère bêta, à la condition que le procédé comprenne également la recristallisation de l'alpha-APM, la collecte du alpha-APM par filtration et le recyclage du filtrat pour utilisation dans la suspension aqueuse du Z-alpha-APM.
Ajioka Masanobu
Enomoto Katashi
Higuchi Chojiro
Kitada Ikumi
Nagatomo Akinori
Mitsui Chemicals Inc.
Sim & Mcburney
LandOfFree
Preparation process of .alpha.-aspartyl-l-phenylalanine... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparation process of .alpha.-aspartyl-l-phenylalanine..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation process of .alpha.-aspartyl-l-phenylalanine... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1969933