Oligonucleotides with amide linkages replacing...

Details Oligonucleotides with amide linkages replacing... Oligonucleotides with amide linkages replacing...

C - Chemistry, Metallurgy

07

H

C07H 19/04 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2159629

Disclosed are oligonucleotide analogs comprising olignucleoside sequences having from 3 to about 200 bases and containing internucleoside linkages wherein amide linkages replace phosphodiester linkages that are the backbones of the natural oligonucleotides that make up RNA and DNA. Also disclosed are bifunctional nucleoside analogs, a process for preparing dimers and trimers therefrom, and a method of using these bifunctional nucleoside intermediates, including the dimers and trimers, to synthesize the above-described oligonucleotide analogs using conventional synthetic organic procedures known in the art, preferably in a solid phase synthesis, more preferably in an automated peptide synthesizer.

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