Methods of extending corneal graft survival

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A61K 31/00 (2006.01) A61K 31/404 (2006.01) A61K 38/17 (2006.01) A61K 39/38 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2476994

The present invention provides a method of extending corneal graft survival following corneal transplantation in a patient by administering to the patient an effective amount of a pharmaceutical composition containing a vascular endothelial growth factor receptor-3 (VEGFR-3) inhibitor, whereby lymphangiogenesis is suppressed in the cornea of the patient.

L'invention concerne une méthode permettant d'allonger la survie d'un greffon cornéen suite à une greffe de la cornée réalisée sur un patient. Cette méthode consiste à administrer au patient une quantité efficace d'une composition pharmaceutique contenant un inhibiteur du récepteur 3 du facteur de croissance vasculaire endothéliale (VEGFR-3). La méthode selon l'invention permet ainsi de supprimer l'angiogenèse lymphatique dans la cornée du patient.

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