Exons 4 and 7 encode separate transactivating and chromatin...

Details Exons 4 and 7 encode separate transactivating and chromatin... Exons 4 and 7 encode separate transactivating and chromatin...

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C12Q 1/68 (2006.01) G01N 33/52 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2331266

This invention identified two domains of ESX, a member of the ETS transcription regulator family, that provide particularly effective targets useful in screening for ESX modulators. One of these domains, ESX exon 4 is a potent transactivator and can be used in constructs to up-or downregulate genes or cDNAs, particularly genes or cDNAs under the control of a promoter containing an Ets element. Another of these domains, exon 7, is capable of acetylation and the level of acetylation can be used in assays for abnormal ESX regulation.

L'invention concerne deux domaines de ESX (à restriction épithéliale par une séquence de sérine), un membre de la famille des régulateurs de transcription ETS, qui constituent des cibles particulièrement efficaces utiles dans le criblage des modulateurs ESX. L'un des domaines, l'éxon 4 de ESX est un transactiveur efficace et peut être utilisé dans des constructions permettant de réguler positivement ou négativement des gènes ou des ADNc, et en particulier des gènes ou des ADNc sous le contrôle d'un promoteur contenant un élément ETS. L'autre domaine, l'éxon 7, est capable d'acétylation et le niveau d'acétylation pouvant être utilisé dans des analyses recherchant une régulation anormale dans ESX.

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