Pharmaceutical solution formulations for pressurised metered...

A - Human Necessities – 61 – K

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A61K 31/57 (2006.01) A61K 9/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2649556

The invention relates to the use a solution formulation for pressurized metered dose inhalers able of providing therapeutical doses of two or more active drug substances to the lung for the manufacture of a medicament for the prevention or treatment of a severe broncho-pulmonary disease, wherein all the active drug substances are fully dissolved in the formulation as well as the two or more active drug substances are delivered with substantially the same particle size distribution.

Utilisation de formulation en solution pour aérosols-doseurs pressurisés fournissant des dosages thérapeutiques de deux ou plus de deux principes actifs au niveau des poumons, pour la fabrication de médicament utilisé dans la prévention ou le traitement de maladie broncho-pulmonaire aigüe, tous les principes actifs étant entièrement dissous dans la formulation, et les deux ou plus de deux principes actifs mentionnés étant fournis selon une distribution de taille de particule sensiblement identique.

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