Reagents for lysergic acid diethylamide immunoassay

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/765 (2006.01) C07D 457/06 (2006.01) C07K 14/47 (2006.01) G01N 33/531 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2209217

The invention provides: - lysergic acid diethylamide (LSD) derivatives of formula Image wherein R1 and R2 are independently selected from H or R3R4; provided that at least one of R1 and R2 is H, but both R1 and R2 are not simultaneously H; R3 is a bond or a saturated straight or branched chain hydrocarbon of 1-10 carbon atoms when R4 is COR5, or R3 is a saturated straight or branched chain hydrocarbon of 1-10 carbon atoms wherein R4 is NHR5; R5 is selected from H, L or LX; L is a linking group; and X is a detector or carrier molecule bound through L, - a reagent for quantitation of lysergic acid and its metabolites in biological fluid samples by an immunoassay, which comprises a label-conjugate of formula I - an improved immunoassay for quantitation of LSD and its metabolites in biological fluid samples which utilizes that label-conjugate.

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