Derivatives of...

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C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4188 (2006.01) A61K 31/4439 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2504131

Derivatives of 6,7-dihydro-5H-imidazo[1,2-.alpha.]imidazole-3-sulfonyl]- pyrrolidine-2-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

L'invention concerne des dérivés de 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-amide d'acide carboxylique présentant un excellent effet inhibiteur sur l'interaction des amides d'acide carboxylique (CAM) et des intégrines leucocytaires; ces dérivés peuvent être utilisés pour le traitement d'une maladie inflammatoire.

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