Methods and compositions relating to a vaccine against...

Details Methods and compositions relating to a vaccine against... Methods and compositions relating to a vaccine against...

A - Human Necessities

61

K

A61K 39/00 (2006.01)

Patent

CA 2612225

An object of the invention is to provide methods and compositions relating to a vaccine against prostate cancer which includes a non- human -primate PSA for administration to humans to provide an immune response against human PSA. More generally, an object of the invention is to provide methods and compositions relating to using a non-human primate xenogeneic antigen (e. g. protein) in a human, wherein, with respect to the non-human primate xenogeneic antigen that is used, there are relatively few interspecies differences between the non- human primate xenogeneic antigen and the human self antigen in order to induce an optimal immune response in the human to its native self antigen.

La présente invention concerne des procédés et des compositions relatifs à un vaccin contre le cancer de la prostate, qui comprennent un antigène spécifique de la prostate (PSA) de primate non humain destiné à être administré à des humains afin d'induire une réponse immunitaire contre le PSA humain. De manière plus générale, cette invention concerne des procédés et des compositions relatifs à l'utilisation d'un antigène xénogénique de primate non humain (par ex. une protéine) chez un humain. Par rapport à l'antigène xénogénique de primate non humain qui est utilisé, il y a relativement peu de différences entre espèces entre l'antigène xénogénique de primate non humain et l'auto-antigène humain, de manière à induire une réponse immunitaire optimale à son auto-antigène natif chez l'humain.

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