C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/4545 (2006.01) A61P 25/06 (2006.01)
Patent
CA 2522024
The present invention is directed to compounds of Formula I and Formula II: (where variables R1, R2, R3, R4, R6, A, B, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Cette invention se rapporte à des composés représentés par la formule (I) et la formule (II) (dans lesquelles les variables R1, R2, R3, R4, R6, A, B, G, J, W, X et Y sont telles que définies dans les pièces descriptives de la demande), qui sont utiles comme antagonistes des récepteurs de CGRP et qui sont utiles dans le traitement et la prévention des maladies dans lesquelles est impliqué le peptide CGRP, telles que maux de tête, migraines et céphalée vasculaire de Horton. Cette invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et de ces compositions dans la prévention ou le traitement des maladies dans lesquelles est impliqué le peptide CGRP.
Burgey Christopher S.
Paone Daniel V.
Shaw Anthony W.
Williams Theresa M.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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