C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 31/436 (2006.01) A61K 31/713 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01) C40B 40/10 (2006.01) G01N 33/68 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2724231
The present invention relates to the identification of polynucleotides and polypeptides having increased expression in tumor blood vessels. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of angiogenesis and the diagnosis and treatment of angiogenesis-related diseases such as cancer.
La présente invention concerne l'identification de polynucléotides et de polypeptides présentant une expression accrue dans les vaisseaux sanguins des tumeurs. L'invention concerne en outre l'utilisation des polynucléotides et polypeptides identifiés, et des inhibiteurs des polynucléotides et des polypeptides, dans la régulation de l'angiogenèse et le diagnostic et le traitement des maladies associées à l'angiogenèse comme le cancer.
Bhati Rajendra
Bone Bradley G.
Demore Nancy Klauber
Patterson Cam
Smart & Biggar
The University Of North Carolina At Chapel Hill
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