Process of producing modified superoxide dismutase

Details Process of producing modified superoxide dismutase Process of producing modified superoxide dismutase

C - Chemistry, Metallurgy

12

N

195/123, 402/270

C12N 9/02 (2006.01) C07D 233/60 (2006.01) C08G 59/14 (2006.01) C08G 65/333 (2006.01)

Patent

CA 2029216

Abstract of the disclosure: A modified superoxide dismutase represented by the formula: Image (wherein R is as defined below; SOD is a residue of superoxide dismutase) is produced, in a shortened period of reaction with a high and constant modification ratio, by reacting a polymeric carbonyldiimidazole derivative represented by the foprmula: Image (wherein R is a residue of a water-soluble polymer having an average molecualr weight of about 2,000 to 10,000) with superoxide dismutase in the presence of a buffer having a pH of 9.0 to 11.0 and a concentration of 0.1 M to 0.5 M, preferably 0.2 M to 0.4 M, at a temperature of 30 to 70°C, prefrably 45 to 60°C. The modified superoxide dismutase thus produced exhibits a suitably prolonged blood half-life.

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