New leukotriene-b antagonists, process for preparing the...

Details New leukotriene-b antagonists, process for preparing the... New leukotriene-b antagonists, process for preparing the...

C - Chemistry, Metallurgy

07

C

C07C 69/736 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/335 (2006.01) A61K 31/44 (2006.01) A61K 31/715 (2006.01) C07C 59/68 (2006.01) C07C 69/712 (2006.01) C07C 235/32 (2006.01) C07D 213/78 (2006.01) C07D 317/22 (2006.01) C07D 317/30 (2006.01) C07D 405/12 (2006.01) C08B 37/16 (2006.01)

Patent

CA 2142821

ABSTRACT OF THE DISCLOSURE Antagonists of the leukotienes-B4 have formula (I), in which n is an integer between 2 and 5, X is a direct bond, 1 to 6 methylene units, an ortho-, meta- or para-substituted phenyl ring or a meta- or para-subtituted pyridin ring; Y is a bond to a hydrogen atom and at the same time to a hydroxy group, an oxygen atom with a double bond or -O-CH2-CH2-O-; R1 and R2 stand for the rest OH, -O-(C1-C4)-alkyl, O-(C3-C6)- cyaloalkyl, -O-(C6-C10)-aryl, -O-(C7-C12)-aralkyl, O-(CH2)- CO-(C6-C10)-aryl or the residue NHR3, in which R3 stands for hydrogen, (C1-C4)-alkyl, (C3-C6)-cycloalkyl or (C7-C1x2)- aralkyl. Also disclosed are the salts of said antagonists with physiologically tolerable bases and their cyclodextrin clathrates.

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