C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/10 (2006.01) A61K 31/496 (2006.01) A61P 1/00 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2393568
Compounds of general formula (I), wherein R1 is se-lected from phenyl, pyridinyl, thiophenyl, furanyl and imidazolyl; each phenyl ring and heteroaromatic ring otpionally and independently be-ing further substituted by 1,2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
La présente invention concerne des composés de formule générale (I), dans laquelle R<1> est choisi parmi phényle, pyridinyle, thiophényle, furanyle et imidazolyle, chaque cycle phénylique et chaque cycle hétéroaromatique étant éventuellement et de façon indépendante également substitué par 1, 2 ou 3 substituants choisis parmi alkyle C1-C6, NO2, CF3, alkoxy C1-C6, chloro, fluoro, bromo et iodo, droits et ramifiés. La présente invention concerne également les sels de ces composés, acceptables d'un point de vue pharmaceutique, des compositions pharmaceutiques comprenant les nouveaux composés, ainsi que l'utilisation des nouveaux composés en thérapie, notamment dans le traitement de la douleur.
Brown William
Plobeck Niklas
Walpole Christopher
Astrazeneca Ab
Fetherstonhaugh & Co.
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