Methods for enriching for quiescent cells in hematopoietic...

Details Methods for enriching for quiescent cells in hematopoietic... Methods for enriching for quiescent cells in hematopoietic...

C - Chemistry, Metallurgy

12

N

C12N 5/0789 (2010.01) C12N 5/078 (2010.01) A61K 35/28 (2006.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01)

Patent

CA 2409452

Described are preferred methods for obtaining a hematopoietic cell population having a large percentage of quiescent cells having a desirable engraftment phenotype. Also described are methods for inducing apoptosis in hematopoietic cells. Further described are culture mediums and cell populations useful in and resulting from methods of the invention.

L'invention concerne des procédés préférés servant à obtenir une population de cellules hématopoïétiques possédant un pourcentage important de cellules quiescentes présentant un phénotype de greffe souhaitable. Elle concerne également des procédés servant à induire l'apoptose dans des cellules hématopoïétiques. Elle concerne, de plus, des milieux de culture et des populations de cellules utiles pour les procédés décrits et résultant desdits procédés.

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