Mutagenesis testing using transgenic non-human animals...

Details Mutagenesis testing using transgenic non-human animals... Mutagenesis testing using transgenic non-human animals...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C12N 1/20 (2006.01) C12N 15/63 (2006.01) C12N 15/72 (2006.01) C12N 15/85 (2006.01) G01N 33/48 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2130081

2130081 9315769 PCTABS00024 The invention describes an assay for monitoring and assessing the mutagenic potential of agents which involves creating and using transgenic non-human organisms carrying a test DNA sequence or sequences that can be examined for spontaneous mutations or induced mutations following exposure to one or more suspected mutagenic agents. In a preferred assay system, the mutagenized test DNA sequences are selectable, thereby increasing the sensitivity of the assay.

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