Gene therapy vectors and cytosine deaminases

Details Gene therapy vectors and cytosine deaminases Gene therapy vectors and cytosine deaminases

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) C12N 5/10 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2738472

This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.

L'invention concerne des cytosines déaminases (CD) modifiées, ainsi que des cellules et un vecteur exprimant ou comprenant de telles CD modifiées. L'invention porte également sur des procédés d'utilisation de telles CD modifiées dans le traitement de maladies ou de troubles.

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