Chemically-modified progenipoietin conjugates

Details Chemically-modified progenipoietin conjugates Chemically-modified progenipoietin conjugates

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/20 (2006.01) A61K 47/48 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2450950

The present invention provides a chemically modified Progenipoietins (ProGPs) prepared by binding a water soluble polymer to the protein. The chemically- modified protein according to the present invention may have a much longer lasting neutrophil-increasing activity than that of the un-modified ProGP, enabling reduced dose and scheduling opportunities.

L'invention concerne des protéines <= progenipoietin >= (ProGP) chimiquement modifiées, préparées par la liaison d'un polymère soluble dans l'eau à ladite protéine. La protéine chimiquement modifiée selon l'invention peut présenter une activité d'augmentation des neutrophiles dont la durée est beaucoup plus importante que celle du ProGP non modifié, ce qui permet d'obtenir des doses réduites et des possibilités de programmation accrues.

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