Method for determining three-dimensional structures of...

G - Physics – 06 – F

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G06F 19/12 (2011.01) G06T 17/00 (2006.01)

Patent

CA 2735395

The present invention relates to a method for determining three-dimensional structures of molecules, particularly, but not exclusively, dynamic organic molecules of biological interest such as peptides, carbohydrates, proteins and drug molecules. A first aspect of the present invention provides a method for generating data representing an ensemble of three-dimen-sional structures of a molecule, the molecule comprising first and second atoms linked by at least one bond, said bond having an associated angle, and the angle varying to generate a plurality of three- dimensional structures of said molecule, the method com-prising: receiving data representing said molecule, said data comprising data indicating variability of said angle; and generating an ensemble of structures such that the angle has an associated value selected based upon said variability. A second aspect of the present invention provides a computer implemented method for simulating the variability of the three- dimensional structure of a molecule.

L'invention concerne un procédé permettant de déterminer les structures tridimensionnelles de molécules, en particulier, mais pas exclusivement, de molécules organiques dynamiques présentant un intérêt biologique, comme les peptides, les glucides, les protéines et les molécules thérapeutiques. Dans un premier aspect, la présente invention propose un procédé permettant de générer des données représentant un ensemble de structures tridimensionnelles d'une molécule, la molécule contenant un premier et un second atome liés par au moins une liaison, ladite liaison ayant un angle associé, et l'angle variant pour générer une pluralité de structures tridimensionnelles de ladite molécule. Le procédé comprend les étapes consistant à recevoir des données représentant ladite molécule, lesdites données comprenant des données indiquant la variabilité dudit angle ; et à générer un ensemble de structures de façon que l'angle ait une valeur associée choisie sur la base de ladite variabilité. Dans un second aspect, la présente invention propose un procédé exécuté sur un ordinateur permettant de simuler la variabilité de la structure tridimensionnelle d'une molécule.

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