Hydroxylation of salicylic acid derivatives

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 229/64 (2006.01) A61K 49/00 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01) C07K 1/113 (2006.01) C07K 2/00 (2006.01) G01N 33/48 (2006.01) G01N 33/53 (2006.01) G01N 33/84 (2006.01)

Patent

CA 2219012

The invention disclosed relates to the novel compound 5-amino tetrahydroxy benzoic acid and derivatives thereof, e.g. pharmaceutically acceptable acid addition salts, to a process for the preparation thereof which involves reacting5-amino salicylic acid with hydroxyl radical, and to a method of using 5-amino tetrahydroxy benzoic acid and derivatives thereof as a biomarker for the presence of hydroxyl radical in biological systems.

Cette invention concerne un nouveau composé, l'acide 5-aminotétrahydroxybenzoïque, et des dérivés de celui-ci, des sels d'addition acides utiles en pharmacie. Elle concerne aussi un procédé de préparation de ces composés, comprenant la réaction de l'acide 5-aminosalicylique avec le radical hydroxyle, et une méthode d'utilisation de l'acide 5-aminotétrahydroxybenzoïque et de ses dérivés comme dépisteur biologique de la présence de radicaux hydroxyles dans des systèmes biologiques.

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