Dipeptoid prodrugs and the use thereof

Details Dipeptoid prodrugs and the use thereof Dipeptoid prodrugs and the use thereof

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/4439 (2006.01) C07K 5/062 (2006.01) C07K 5/065 (2006.01) C07K 5/068 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01)

Patent

CA 2746711

The present application relates to dipeptide-like prodrug derivatives of 2-amino-6-({[2-(4--chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[2,3- dihydroxypropyl]oxy}phenyl)pyridine--3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.

La présente invention concerne des dérivés promédicamenteux de type dipeptide de la formule (I) dans laquelle RPD représente un groupe de la formule (Ia), (Ib), (Ic) ou (Id) où # représente le point de liaison avec l'atome O, son procédé de production, son utilisation pour le traitement et/ou la prophylaxie de maladies ainsi que son utilisation pour la fabrication de médicaments pour le traitement et/ou la prophylaxie de maladies, notamment de maladies cardiovasculaires.

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