A combination of anti-erbb-2 monoclonal antibodies and...

Details A combination of anti-erbb-2 monoclonal antibodies and... A combination of anti-erbb-2 monoclonal antibodies and...

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/32 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2120745

2120745 9400136 PCTABS00030 The present invention relates to a combination of at least two monolconal antibodies which are capable of preventing and treating human malignancies wherein the malignant cells overexpress gp185erbB-2. The monoclonal antibodies of the combination recognize different epitopes of the gp185 expression product of erbB-2, therefore, the antibodies do not cross react with each other. Preferably, the combination decreases the expression product of the erbB-2 gene. In another embodiment, the combination does not essentially increase tyrosine phosphorylation of the gp185 expression product.

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