Inhibitors of phosphatidyl myo-inositol cycle

Details Inhibitors of phosphatidyl myo-inositol cycle Inhibitors of phosphatidyl myo-inositol cycle

C - Chemistry, Metallurgy

07

F

C07F 9/40 (2006.01) A61K 31/66 (2006.01) C07F 9/117 (2006.01) A61K 31/22 (2006.01) A61K 31/265 (2006.01) C07C 53/134 (2006.01) C07C 55/28 (2006.01) C07C 59/125 (2006.01) C07C 59/305 (2006.01) C07C 69/013 (2006.01) C07C 69/96 (2006.01)

Patent

CA 2335995

The present invention relates to the preparation and biological activity of 3- deoxy-D-myo-inositol ether lipid analogs as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth. The compounds of the present invention are useful as anti-tumor agents which effectively inhibit the growth of mammalian cells.

Préparation et activité biologique d'analogues lipides de 3-désoxy-D-myo-inositol éther en tant qu'inhibiteurs de la signalisation par la phosphatidylinositol-3-kinase et de la croissance cellulaire tumorale. Les composés selon la présente invention sont utiles en tant qu'agents anti-tumoraux qui inhibent efficacement la croissance de cellules de mammifères.

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