Water insoluble derivatives of polyanionic polysaccharides

Details Water insoluble derivatives of polyanionic polysaccharides Water insoluble derivatives of polyanionic polysaccharides

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01) A61L 31/00 (2006.01) A61L 31/04 (2006.01) C08B 11/20 (2006.01) C08B 37/08 (2006.01) C08J 3/075 (2006.01) C08L 5/08 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2394582

A water insoluble, biocompatible gel is prepared by reacting carboxymethylcellulose and a carbodiimide, wherein the reaction is conducted in an aqueous medium containing a water miscible organic solvent, such as a lower alkanol, an alkyl pyrrolidone, DMSO or acetone. The present method permits the reaction to contain higher concentrations of carboxymethylcellulose and less carbodiimide than conventional methods.

L'invention concerne un gel biocompatible insoluble dans l'eau, préparé par réaction de carboxyméthylcellulose et d'un carbodiimide, dans un milieu aqueux contenant un solvant organique miscible dans l'eau, par exemple un alcanol inférieur, une pyrrolidone d'alkyle, DMSO ou de l'acétone. Cette méthode permet à la réaction de contenir des concentrations supérieures de carboxyméthycellulose et moins de carbodiimide que dans les méthodes conventionnelles.

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