Methods for altering insulin secretion

Details Methods for altering insulin secretion Methods for altering insulin secretion

A - Human Necessities

61

K

A61K 31/15 (2006.01) A61K 31/16 (2006.01) A61K 31/519 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2558810

Modulation of the activity of glucocorticoid inducible kinase SGK1 in pancreatic islet cells restores insulin release. Also disclosed are methods and compounds useful for the treatment of glucocorticoid induced diabetes mellitus type-2.

Selon l'invention, la modulation de l'activité de la kinase SGK1 inductible par les glucocorticoïdes dans les cellules des îlots pancréatiques permet de rétablir la libération d'insuline. L'invention concerne des méthodes et des composés utiles pour traiter le diabète sucré de type 2 induit par les glucocorticoïdes.

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